Engineering in Translational Medicine

Detalles Bibliográficos
Otros autores o Colaboradores:	Cai, Weibo (ed.)
Formato:	Libro
Lengua:	inglés
Datos de publicación:	London : Springer London : Imprint: Springer, 2014.
Temas:	Radiology. Biophysics. Biological physics. Medical physics. Radiation. Biomedical engineering. Biomaterials. Engineering. Imaging / Radiology.
Acceso en línea:	http://dx.doi.org/10.1007/978-1-4471-4372-7
Resumen:	This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for scientists and students both new to engineering/translational medicine and currently working in this area.
Descripción Física:	xix, 999 p. : il.
ISBN:	9781447143727
DOI:	10.1007/978-1-4471-4372-7

Tabla de Contenidos:

1. Engineering in Translational Medicine: An Introduction
2. Stem Cells: The Holy Grail of Regenerative Medicine
3. Engineering T Cells to Target Tumor Cells
4. Engineering Biomaterials for Anchorage-Dependent and Non-Anchorage-Dependent Therapeutic Cell Delivery in Translational Medicine
5. Tissue Engineering Applications for Peripheral Nerve Repair
6. Structure, Function and Development of Blood Vessels: Lessons for Tissue engineering
7. Engineering Gene Activated Matrices for the Repair of Articular Cartilage Defect
8. Engineering Luciferases for Assays and Imaging
9. Engineered Split Reporter Systems for Molecular Imaging of Protein-Protein Interactions in Living Subjects
10. Engineering Aspects of Bioluminescence Resonance Energy Transfer Systems
11. Antibody Engineering in Translational Medicine
12. Engineered Affibodies in Translational Medicine
13. Alternative Protein Scaffolds for Molecular Imaging and Therapy
14. Engineering Multivalent and Multispecific Protein Therapeutics
15. Engineering Aptamers for Biomedical Applications: Part 1
16. Engineering Aptamers for Biomedical Applications: Part 2
17. Engineering DNA Vaccines for Cancer Therapy
18. Multifunctional Nanoscale Delivery Systems for Nucleic Acids
19. Engineering Nanomaterials for Biosensors and Therapeutics
20. Engineering Fluorescent Nanoparticles for Biomedical Applications
21. Magnetic Nanoparticles for Biomedical Applications: From Diagnosis to Treatment to Regeneration
22. Engineering Upconversion Nanoparticles for Biomedical Imaging and Therapy
23. Engineering of Mesoporous Silica Nanoparticles for in Vivo Cancer Imaging and Therapy
24. Engineering Carbon Nanomaterials for Stem Cell-Based Tissue Engineering
25. Engineering Peptide-Based Carriers for Drug and Gene Delivery
26. Activation Approaches on Delivery of Imaging and Therapeutic Agents
27. Opportunities for New Photodynamic Molecular Beacon Designs
28. Engineering the next generation PET detectors
29. Photoacoustic Imaging: Development of Imaging Systems and Molecular Agents
30. Engineering Miniature Imaging Instruments
31. Engineering Small Animal Conformal Radiotherapy Systems
32. Plasmonic Nanobubbles for Cancer Theranostics
33. Cell-Based Microfluidic Assays in Translational Medicine
34. Engineering of Photo-Manipulatable Hydrogels for Translational Medicine
35. Engineering AApeptides for Translational Medicine.

foreach (glob($this->path . '/sess_*') as $filename) { if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); } } return true; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return true; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

Environment & details:

GET Data empty

POST Data empty

Files empty

Key	Value
ui	"standard"
VUFIND_SESSION	"424s0lqiq663389s6vt9j5cs22"
language	"es"

Session

Key	Value
__Laminas	array:2 [`"_REQUEST_ACCESS_TIME" => 1738347772.8121 "_VALID" => array:1 [ "Laminas\Session\Validator\Id" => "424s0lqiq663389s6vt9j5cs22" ]`]
SessionState	Laminas\Stdlib\ArrayObject {#906}
FlashMessenger	Laminas\Stdlib\ArrayObject {#1507}
SessionHelper	Laminas\Stdlib\ArrayObject {#1671}

Server/Request Data

Key	Value
REDIRECT_VUFIND_ENV	"development"
REDIRECT_VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
REDIRECT_HTTPS	"on"
REDIRECT_SSL_TLS_SNI	"catalogo.bibliotecas.unlp.edu.ar"
REDIRECT_STATUS	"200"
VUFIND_ENV	"development"
VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
HTTPS	"on"
SSL_TLS_SNI	"catalogo.bibliotecas.unlp.edu.ar"
HTTP_ACCEPT	"/"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_COOKIE	"ui=standard; VUFIND_SESSION=424s0lqiq663389s6vt9j5cs22; language=es"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_HOST	"catalogo.bibliotecas.unlp.edu.ar"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin"
SERVER_SIGNATURE	"<address>Apache/2.4.52 (Ubuntu) Server at catalogo.bibliotecas.unlp.edu.ar Port 443</address>\n"
SERVER_SOFTWARE	"Apache/2.4.52 (Ubuntu)"
SERVER_NAME	"catalogo.bibliotecas.unlp.edu.ar"
SERVER_ADDR	"172.17.0.170"
SERVER_PORT	"443"
REMOTE_ADDR	"3.17.78.184"
DOCUMENT_ROOT	"/usr/local/vufind/public"
REQUEST_SCHEME	"https"
CONTEXT_PREFIX	""
CONTEXT_DOCUMENT_ROOT	"/usr/local/vufind/public"
SERVER_ADMIN	"webmaster@bibliotecas.unlp.edu.ar"
SCRIPT_FILENAME	"/usr/local/vufind/public/index.php"
REMOTE_PORT	"34839"
REDIRECT_URL	"/Record/dfi.27436/TOC"
GATEWAY_INTERFACE	"CGI/1.1"
SERVER_PROTOCOL	"HTTP/1.1"
REQUEST_METHOD	"GET"
QUERY_STRING	""
REQUEST_URI	"/Record/dfi.27436/TOC"
SCRIPT_NAME	"/index.php"
PHP_SELF	"/index.php"
REQUEST_TIME_FLOAT	1738347772.7991
REQUEST_TIME	1738347772

Environment Variables empty

Registered Handlers

0. Whoops\Handler\PrettyPageHandler

Environment & details:

GET Data empty

POST Data empty

Files empty

Key	Value
ui	"standard"
VUFIND_SESSION	"424s0lqiq663389s6vt9j5cs22"
language	"es"

Session

Key	Value
__Laminas	array:2 [`"_REQUEST_ACCESS_TIME" => 1738347772.8121 "_VALID" => array:1 [ "Laminas\Session\Validator\Id" => "424s0lqiq663389s6vt9j5cs22" ]`]
SessionState	Laminas\Stdlib\ArrayObject {#906}
FlashMessenger	Laminas\Stdlib\ArrayObject {#1507}
SessionHelper	Laminas\Stdlib\ArrayObject {#1671}

Server/Request Data

Key	Value
REDIRECT_VUFIND_ENV	"development"
REDIRECT_VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
REDIRECT_HTTPS	"on"
REDIRECT_SSL_TLS_SNI	"catalogo.bibliotecas.unlp.edu.ar"
REDIRECT_STATUS	"200"
VUFIND_ENV	"development"
VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
HTTPS	"on"
SSL_TLS_SNI	"catalogo.bibliotecas.unlp.edu.ar"
HTTP_ACCEPT	"/"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_COOKIE	"ui=standard; VUFIND_SESSION=424s0lqiq663389s6vt9j5cs22; language=es"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_HOST	"catalogo.bibliotecas.unlp.edu.ar"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin"
SERVER_SIGNATURE	"<address>Apache/2.4.52 (Ubuntu) Server at catalogo.bibliotecas.unlp.edu.ar Port 443</address>\n"
SERVER_SOFTWARE	"Apache/2.4.52 (Ubuntu)"
SERVER_NAME	"catalogo.bibliotecas.unlp.edu.ar"
SERVER_ADDR	"172.17.0.170"
SERVER_PORT	"443"
REMOTE_ADDR	"3.17.78.184"
DOCUMENT_ROOT	"/usr/local/vufind/public"
REQUEST_SCHEME	"https"
CONTEXT_PREFIX	""
CONTEXT_DOCUMENT_ROOT	"/usr/local/vufind/public"
SERVER_ADMIN	"webmaster@bibliotecas.unlp.edu.ar"
SCRIPT_FILENAME	"/usr/local/vufind/public/index.php"
REMOTE_PORT	"34839"
REDIRECT_URL	"/Record/dfi.27436/TOC"
GATEWAY_INTERFACE	"CGI/1.1"
SERVER_PROTOCOL	"HTTP/1.1"
REQUEST_METHOD	"GET"
QUERY_STRING	""
REQUEST_URI	"/Record/dfi.27436/TOC"
SCRIPT_NAME	"/index.php"
PHP_SELF	"/index.php"
REQUEST_TIME_FLOAT	1738347772.7991
REQUEST_TIME	1738347772

Environment Variables empty

Registered Handlers

0. Whoops\Handler\PrettyPageHandler

Engineering in Translational Medicine

Ejemplares similares

Environment & details:

Environment & details: